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Article

Mycn deficiency underlies the development of orofacial clefts in mice and humans.

Human molecular genetics - 3 Mar 2022

Yang Ruihuan, Li Ruyi, Huang Zhuo, Zuo Yining, Yue Haitang, Wu Hailin, Gu Fan, Wang Fei, He Miao, Bian Zhuan

Abstract excerpt

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is the most common subphenotype of non-syndromic orofacial clefts arising from genetic and/or environmental perturbations during embryonic development. We previously identified 2p24.2 as a risk locus associated with NSCL/P in the Chinese Han population, and MYCN is a candidate risk gene in this region. To understand the potential function of MYCN in...

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PMID: 34590686
DOI: 10.1093/hmg/ddab288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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