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Article

Msx1 deficiency interacts with hypoxia and induces a morphogenetic regulation during mouse lip development.

Development (Cambridge, England) - 24 Jun 2020

Nakatomi Mitsushiro, Ludwig Kerstin U, Knapp Michael, Kist Ralf, Lisgo Steven, Ohshima Hayato, Mangold Elisabeth, Peters Heiko

Abstract excerpt

Nonsyndromic clefts of the lip and palate are common birth defects resulting from gene-gene and gene-environment interactions. Mutations in human MSX1 have been linked to orofacial clefting and we show here that Msx1 deficiency causes a growth defect of the medial nasal process (Mnp) in mouse embryos. Although this defect alone does not disrupt lip formation, Msx1-deficient embryos develop a cleft lip when the...

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PMID: 32467233
DOI: 10.1242/dev.189175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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