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Article

IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming

29 Sept 2021

Abstract excerpt

To understand the role of polyploid giant cancer cells (PGCCs) in drug resistance and disease relapse, we examined the mRNA expression profile of PGCCs following treatment with paclitaxel in ovarian cancer cells. An acute activation of IL-6 dominated senescence-associated secretory phenotype lasted 2-3 weeks and declined during the termination phase of polyploidy. IL-6 activates embryonic stemness during the...

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PMID: 34588424
DOI: 10.1038/s41389-021-00349-4

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