Article
Large Evolutionary Rate Heterogeneity among and within HIV-1 Subtypes and CRFs.
Viruses - 26 Aug 2021
Nasir Arshan, Dimitrijevic Mira, Romero-Severson Ethan, Leitner Thomas
Abstract excerpt
HIV-1 is a fast-evolving, genetically diverse virus presently classified into several groups and subtypes. The virus evolves rapidly because of an error-prone polymerase, high rates of recombination, and selection in response to the host immune system and clinical management of the infection. The rate of evolution is also influenced by the rate of virus spread in a population and nature of the outbreak, among...
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