Physical activity and Mediterranean diet as potential modulators of osteoprotegerin and soluble RANKL in gBRCA1/2 mutation carriers: results of the lifestyle intervention pilot study LIBRE-1.

doi:10.1007/s10549-021-06400-7

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Physical activity and Mediterranean diet as potential modulators of osteoprotegerin and soluble RANKL in gBRCA1/2 mutation carriers: results of the lifestyle intervention pilot study LIBRE-1.

Breast cancer research and treatment - 1 Dec 2021

Neirich Leonie, Yahiaoui-Doktor Maryam, Lammert Jacqueline, Basrai Maryam, Seethaler Benjamin, Berling-Ernst Anika, Ramser Juliane, Quante Anne S, Schmidt Thorsten, Niederberger Uwe, Rhiem Kerstin, Schmutzler Rita, Engel Christoph, Bischoff Stephan C, Halle Martin, Kiechle Marion, Grill Sabine

Abstract excerpt

PURPOSE: Emerging evidence suggests that the progesterone-mediated receptor activator of nuclear factor κB (RANK)/soluble RANK ligand (sRANKL)/osteoprotegerin (OPG) pathway plays an important role in mammary carcinogenesis and is hyperactivated in germline (g)BRCA1/2 mutation carriers. We analyzed the effects of a 3-month intensive lifestyle intervention within the LIBRE-1 study on the serum levels of OPG and...

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PMID: 34570303
DOI: 10.1007/s10549-021-06400-7
PMCID: PMC8558155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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