Article
Effects of lifestyle intervention in BRCA1/2 mutation carriers on nutrition, BMI, and physical fitness (LIBRE study): study protocol for a randomized controlled trial.
Trials - 29 Jul 2016
Kiechle Marion, Engel Christoph, Berling Anika, Hebestreit Katrin, Bischoff Stephan C, Dukatz Ricarda, Siniatchkin Michael, Pfeifer Katharina, Grill Sabine, Yahiaoui-Doktor Maryam, Kirsch Ellen, Niederberger Uwe, Enders Ute, Löffler Markus, Meindl Alfons, Rhiem Kerstin, Schmutzler Rita, Erickson Nicole, Halle Martin
Abstract excerpt
BACKGROUND: Women with highly penetrant BRCA mutations have a 55-60 % lifetime risk for breast cancer and a 16-59 % lifetime risk of developing ovarian cancer. However, penetrance differs interindividually, indicating that environmental and behavioral factors may modify this risk. It is well documented that the risk for sporadic breast cancer disease can be modified by changing lifestyle factors that primarily...
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