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Macrophages mediated delivery of chlorin e6 and treatment of lung cancer by photodynamic reprogramming.

International immunopharmacology - 1 Nov 2021

Yu Ting-Ting, Sang Xue-Yu, Han Ning, Peng Xing-Chun, Li Qi-Rui, Xu Xiang, Xiao Rong-Cheng, Xu Hua-Zhen, Chen Xiao, Wang Mei-Fang, Li Tong-Fei

Abstract excerpt

Photodynamic therapy (PDT) is an emerging anti-tumor strategy.Photosensitizer chlorin e6 (Ce6) can induce photodynamic effect to selectively damage lung cancer cells.In order to further improve its tumor targeting ability, macrophages can be applied as carrier to deliver Ce6 to lung cancer.Tumor associated macrophages (TAM) are important immunocytes in lung cancer immune microenvironment. TAM play crucial role in...

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PMID: 34562845
DOI: 10.1016/j.intimp.2021.108164

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