Article
Molecular surveillance of anti-malarial drug resistance in Democratic Republic of Congo: high variability of chloroquinoresistance and lack of amodiaquinoresistance.
Malaria journal - 20 Mar 2020
Yobi Doudou M, Kayiba Nadine K, Mvumbi Dieudonné M, Boreux Raphael, Kabututu Pius Z, Situakibanza Hippolyte N T, Likwela Joris L, De Mol Patrick, Okitolonda Emile W, Speybroeck Niko, Mvumbi Georges L, Hayette Marie-Pierre
Abstract excerpt
BACKGROUND: The loss of chloroquine (CQ) effectiveness has led to its withdrawal from national policies as a first-line treatment for uncomplicated malaria in several endemic countries, such as the Democratic Republic of Congo (DRC). The K76T mutation on the pfcrt gene has been identified as a marker of CQ resistance and the SVMNT haplotype in codons 72-76 on the same gene has been associated with resistance to...
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