Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of vaginal distention on cell senescence in an animal model of pelvic organ prolapse.

Tissue & cell - 1 Dec 2021

Hare Adam M, Gaddam Neha G, Shi Haolin, Acevedo Jesus F, Word R Ann, Florian-Rodriguez Maria E

Abstract excerpt

OBJECTIVE: Cellular senescence, associated with aging, leads to impaired tissue regeneration. We hypothesize that vaginal injury initiates cell senescence, further propagated during aging resulting in pelvic organ prolapse (POP). Our objective was to employ a mouse model of POP (Fibulin-5 knockout mice, Fbln5-/-) to determine if vaginal distention leads to cellular senescence and POP. METHODS: 6wk old females...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to Biomarkers
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Extracellular Matrix Proteins

Share to Recombinant Proteins

Share to Stromal Cells

Share to Vagina

Source

Identifiers

PMID: 34560406
DOI: 10.1016/j.tice.2021.101652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Impact of vaginal distention on cell senescence in an animal model of pelvic organ prolapse.PMID 34560406Read ↗

Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review).Semantic proximity Read ↗

Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical functionSemantic proximity Read ↗

A Cell-Based Therapeutic Strategy for Stress Urinary Incontinence: Functional and Molecular Evidence from Decidua-Derived Mesenchymal Stromal CellsSemantic proximity Read ↗

Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient miceSemantic proximity Read ↗

MAPK15 Attenuates Intestinal Epithelial Cell Senescence-Like Phenotype to Regulate Gut Homeostasis and Inflammation by Phosphorylating Suz12 to Suppress Drp1-Mediated Mitochondrial Fission Damage.Semantic proximity Read ↗

Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans.Semantic proximity Read ↗

[Connective tissue and prolapse genesis].Semantic proximity Read ↗

Radiation cystitis modeling: A comparative study of bladder fibrosis radio-sensitivity in C57BL/6, C3H, and BALB/c mice.Semantic proximity Read ↗

Polyploid Superficial Cells that Maintain the Urothelial Barrier Are Produced via Incomplete Cytokinesis and EndoreplicationSemantic proximity Read ↗

Using the novel pelvic organ prolapse histologic quantification system to identify phenotypes in uterosacral ligaments in women with pelvic organ prolapse.Semantic proximity Read ↗

Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.