Article
Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans.
The Journal of clinical investigation - 1 May 2011
Budatha Madhusudhan, Roshanravan Shayzreen, Zheng Qian, Weislander Cecilia, Chapman Shelby L, Davis Elaine C, Starcher Barry, Word R Ann, Yanagisawa Hiromi
Abstract excerpt
Pelvic organ prolapse (POP) is a common condition affecting almost half of women over the age of 50. The molecular and cellular mechanisms underlying this condition, however, remain poorly understood. Here we have reported that fibulin-5, an integrin-binding matricellular protein that is essential for elastic fiber assembly, regulated the activity of MMP-9 to maintain integrity of the vaginal wall and prevented...
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