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Article

MicroRNA‑218 inhibits the malignant phenotypes of glioma by modulating the TNC/AKT/AP‑1/TGFβ1 feedback signaling loop.

International journal of molecular medicine - 1 Nov 2021

Dang Siwen, Zhang Rui, Tian Sijia, Hou Peng, Li Gang, Ji Meiju

Abstract excerpt

Gliomas are the most malignant and common tumors of the human brain, and the prognosis of glioma patients is extremely poor. MicroRNAs (miRNAs or miRs) play critical roles in different types of cancer by performing post‑transcriptional regulation of gene expression. Although miR‑218 has been demonstrated to be decreased in gliomas, its role in gliomas remains largely unknown. miR‑218 expression was analyzed in...

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Identifiers

PMID: 34558654
DOI: 10.3892/ijmm.2021.5038
PMCID: PMC8480380

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