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Article

Tissue-Resident-Memory CD8+ T Cells Bridge Innate Immune Responses in Neighboring Epithelial Cells to Control Human Genital Herpes.

Frontiers in immunology - 1 Jan 2021

Peng Tao, Phasouk Khamsone, Sodroski Catherine N, Sun Sijie, Hwangbo Yon, Layton Erik D, Jin Lei, Klock Alexis, Diem Kurt, Magaret Amalia S, Jing Lichen, Laing Kerry, Li Alvason, Huang Meei-Li, Mertens Max, Johnston Christine, Jerome Keith R, Koelle David M, Wald Anna, Knipe David M, Corey Lawrence, Zhu Jia

Abstract excerpt

Tissue-resident-memory T cells (TRM) populate the body's barrier surfaces, functioning as frontline responders against reencountered pathogens. Understanding of the mechanisms by which CD8TRM achieve effective immune protection remains incomplete in a naturally recurring human disease. Using laser capture microdissection and transcriptional profiling, we investigate the impact of CD8TRM on the tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

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Source

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Identifiers

PMID: 34552595
DOI: 10.3389/fimmu.2021.735643
PMCID: PMC8450389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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