Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE).

doi:10.1016/j.cancergen.2021.08.004

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Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE).

Cancer genetics - 1 Nov 2021

Swami Nishwant, Hwang William L, Guo Jimmy A, Hoffman Hannah, Abramowitz Matthew C, Elbakouny Ziad, Beltran Himisha, Chipidza Fallon, Choueiri Toni, Pra Alan Dal, Huang Franklin, Kaochar Salma, Kantoff Philip, Kim Daniel W, Kishan Amar U, Kobetz Erin, Marinac Catherine, Mucci Lorelei A, Muralidhar Vinayak, Pollack Alan, Sanford Nina N, Schaeffer Edward M, Spratt Daniel E, Zhao Shuang G, Rebbeck Timothy R, Nguyen Paul L, Feng Felix Y, Mahal Brandon A, Alshalalfa Mohammed

Abstract excerpt

BACKGROUND: High tumor mutation burden (TMB) and total mutation count (TMC) can be predictive of better response to immune checkpoint blockade (ICB). Nevertheless, TMB and TMC are limited by variation across cancers and inconsistent definitions due to different profiling methods (targeted vs whole genome sequencing). Our objective was to identify genomic alterations (GAs) associated with ICB response and builds a...

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PMID: 34551377
DOI: 10.1016/j.cancergen.2021.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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