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Article

Targeting the Lnc-OPHN1-5/androgen receptor/hnRNPA1 complex increases Enzalutamide sensitivity to better suppress prostate cancer progression.

Cell death & disease - 20 Sept 2021

Zhang Meng, Sun Yin, Huang Chi-Ping, Luo Jie, Zhang Li, Meng Jialin, Liang Chaozhao, Chang Chawnshang

Abstract excerpt

Long non-coding RNAs (lncRNAs) have been found to play critical roles in regulating gene expression, but their function in translational control is poorly understood. We found lnc-OPHN1-5, which lies close to the androgen receptor (AR) gene on chromosome X, increased prostate cancer (PCa) Enzalutamide (Enz) sensitivity via decreasing AR protein expression and associated activity. Mechanism dissection revealed...

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Identifiers

PMID: 34545067
DOI: 10.1038/s41419-021-03966-4
PMCID: PMC8452728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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