Article
Prophylactic Inhibition of Colonization by Streptococcus pneumoniae with the Secondary Bile Acid Metabolite Deoxycholic Acid.
Infection and immunity - 16 Nov 2021
Vidal Jorge E, Wier Meagan N, A Angulo-Zamudio Uriel, McDevitt Erin, Jop Vidal Ana G, Alibayov Babek, Scasny Anna, Wong Sandy M, Akerley Brian J, McDaniel Larry S
Abstract excerpt
Streptococcus pneumoniae colonizes the nasopharynx of children and the elderly but also kills millions worldwide yearly. The secondary bile acid metabolite deoxycholic acid (DoC) affects the viability of human pathogens but also plays multiple roles in host physiology. We assessed in vitro the antimicrobial activity of DoC and investigated its potential to eradicate S. pneumoniae colonization using a model of...
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