Article
Histone-like nucleoid-structuring protein (H-NS) regulatory role in antibiotic resistance in Acinetobacter baumannii.
Scientific reports - 16 Sept 2021
Rodgers Deja, Le Casin, Pimentel Camila, Tuttobene Marisel R, Subils Tomás, Escalante Jenny, Nishimura Brent, Vescovi Eleonora García, Sieira Rodrigo, Bonomo Robert A, Tolmasky Marcelo E, Ramirez Maria Soledad
Abstract excerpt
In the multidrug resistant (MDR) pathogen Acinetobacter baumannii the global repressor H-NS was shown to modulate the expression of genes involved in pathogenesis and stress response. In addition, H-NS inactivation results in an increased resistance to colistin, and in a hypermotile phenotype an altered stress response. To further contribute to the knowledge of this key transcriptional regulator in A. baumannii...
Topics
- Acinetobacter baumannii
- Bacterial Proteins
- Biofilms
- Drug Resistance, Multiple, Bacterial
- Gene Expression Regulation, Bacterial
- Genotype
- Histones
- Microbial Sensitivity Tests
- Phenotype
- Quorum Sensing