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[Clinical characteristics and therapeutic effect of TP53 variant in patients with acute leukemia].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 10 Oct 2021

Mi Ruihua, Guo Zhen, Liu Wen, Hu Jieying, Fan Ruihua, Chen Lin, Liu Jia, Wei Xudong

Abstract excerpt

OBJECTIVE: To explore the clinical characteristics and prognostic values of TP53 gene variant in patients with acute leukemia(AL). METHODS: The clinical data of 44 newly diagnosed AL patients with TP53 variant detected by next generation sequencing (NGS) were analyzed retrospectively. Targeted sequencing technique containing 108 leukemia-related genes was used for variant analysis, and conventional R-banding...

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PMID: 34625931
DOI: 10.3760/cma.j.cn511374-20200414-00262

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