Discovery and optimization of natural-based nanomolar c-Kit inhibitors via in silico and in vitro studies.

Abstract excerpt

c-Kit is a receptor tyrosine kinase which is involved in intracellular signaling and mutations of c-Kit have been associated with various types of cancers. Investigations have shown that inhibition of c-Kit, using tyrosine kinase inhibitors, yielded promising results in cancer treatment marking it as a promising target for cancer therapy. However, the emerging resistance for the current therapy necessitates the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Enzyme Inhibitors
• Share to Imatinib Mesylate