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Article

Rate-Perturbing Single Amino Acid Mutation for Hydrolases: A Statistical Profiling.

The journal of physical chemistry. B - 30 Sept 2021

Yan Bailu, Ran Xinchun, Jiang Yaoyukun, Torrence Sarah K, Yuan Li, Shao Qianzhen, Yang Zhongyue J

Abstract excerpt

Hydrolases are a critical component for modern chemical, pharmaceutical, and environmental sciences. Identifying mutations that enhance catalytic efficiency presents a roadblock to design and to discover new hydrolases for broad academic and industrial uses. Here, we report the statistical profiling for rate-perturbing mutant hydrolases with a single amino acid substitution. We constructed an integrated...

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Identifiers

PMID: 34524819
DOI: 10.1021/acs.jpcb.1c05901

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