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Mutation of the sixth amino acid of the Rep protein has no effect on porcine circovirus 2b but enhances porcine circovirus 2d replication in vitro.

Archives of virology - 1 Nov 2021

Wu Xiaoyan, Wang Shuo, Xin Changxun, Li Chen, Shi Jianli, Peng Zhe, Liu Chang, Han Hong, Yang Ying, Tian Yao, Li Jiaxin, Xu Shaojian, Li Jun, Zhang Fan

Abstract excerpt

Porcine circovirus type 2 (PCV2) is the etiological agent of post-weaning multisystemic wasting syndrome (PMWS). The original prevalent genotype, PCV2a, has been replaced by genotypes 2b and 2d in the swine population worldwide. The Rep protein is critical for viral replication. Comparison of a large number of Rep protein amino acid (aa) sequences showed that three sites distinguish genotype 2b from genotype 2d....

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PMID: 34524537
DOI: 10.1007/s00705-021-05217-5

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