Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-146a-5p-mediated suppression on trophoblast cell progression and epithelial-mesenchymal transition in preeclampsia

13 Sept 2021

Abstract excerpt

OBJECTIVE: This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE). METHODS: Expression levels of miR-146a-5p and Wnt2 in preeclamptic and normal placentae were quantified. Trophoblast cells (HTR-8) were separately transfected with miR-146a-5p mimic, miR-146a-5p inhibitor, pcDNA3.1-Wnt2 or sh-Wnt2, and then the expression levels of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Maternal and fetal healthcare
Share to Pregnancy and preeclampsia studies
Share to Reproductive System and Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34517910
DOI: 10.1186/s40659-021-00351-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-146a-5p-mediated suppression on trophoblast cell progression and epithelial-mesenchymal transition in preeclampsiaPMID 34517910Read ↗

Wnt5a inhibited human trophoblast cell line HTR8/SVneo invasion: implications for early placentation and preeclampsiaSemantic proximity Read ↗

The decreased lncRNA ZEB2‐AS1 in pre‐eclampsia controls the trophoblastic cell line HTR‐8/SVneo's invasive and migratory abilities via the miR‐149/PGF axisSemantic proximity Read ↗

Involvement of WNT2 in trophoblast cell behavior in preeclampsia developmentSemantic proximity Read ↗

miR-146b-5p downregulates IRAK1 and ADAM19 to suppress trophoblast proliferation, invasion, and migration in miscarriageSemantic proximity Read ↗

Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placentaSemantic proximity Read ↗

MicroRNA-513c-5p is involved in the pathogenesis of preeclampsia by regulating of low-density lipoprotein receptor-associated protein 6Semantic proximity Read ↗

Wnt/β-catenin signaling pathway in trophoblasts and abnormal activation in preeclampsiaSemantic proximity Read ↗

MiR-221-3p is down-regulated in preeclampsia and affects trophoblast growth, invasion and migration partly via targeting thrombospondin 2Semantic proximity Read ↗

Up-regulation of miR-299 suppressed the invasion and migration of HTR-8/SVneo trophoblast cells partly via targeting HDAC2 in pre-eclampsiaSemantic proximity Read ↗

Identification of microRNA signature in the progression of gestational trophoblastic diseaseSemantic proximity Read ↗

Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expressionSemantic proximity Read ↗

Human placental trophoblast invasion and differentiation: a particular focus on Wnt signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.