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Machine learning-based integration reveals reliable biomarkers and potential mechanisms of NASH progression to fibrosis

11 Apr 2025

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) affects about 25% of adults worldwide. Its advanced form, non-alcoholic steatohepatitis (NASH), is a major cause of liver fibrosis, but there are no non-invasive tests for diagnosing or preventing it. In our study, we analyzed data from multiple sources to find crucial genes linked to NASH fibrosis. We built diagnostic models using 103 machine learning algorithms and...

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PMID: 40217090
DOI: 10.1038/s41598-025-97670-4

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