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Article

Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling.

Communications biology - 9 Sept 2021

Bock Lucy J, Ferguson Philip M, Clarke Maria, Pumpitakkul Vichayanee, Wand Matthew E, Fady Paul-Enguerrand, Allison Leanne, Fleck Roland A, Shepherd Matthew J, Mason A James, Sutton J Mark

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic pathogen capable of stably adapting to the antiseptic octenidine by an unknown mechanism. Here we characterise this adaptation, both in the laboratory and a simulated clinical setting, and identify a novel antiseptic resistance mechanism. In both settings, 2 to 4-fold increase in octenidine tolerance was associated with stable mutations and a specific 12 base pair...

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Identifiers

PMID: 34504285
DOI: 10.1038/s42003-021-02566-4
PMCID: PMC8429429

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