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Article

A Longitudinal Analysis of Early Lesion Growth in Presymptomatic Patients with Cerebral Adrenoleukodystrophy.

AJNR. American journal of neuroradiology - 1 Oct 2021

Mallack E J, Askin G, van de Stadt S, Caruso P A, Musolino P L, Engelen M, Niogi S N, Eichler F S

Abstract excerpt

BACKGROUND AND PURPOSE: Cerebral adrenoleukodystrophy is a devastating neurological disorder caused by mutations in the ABCD1 gene. Our aim was to model and compare the growth of early cerebral lesions from longitudinal MRIs obtained in presymptomatic patients with progressive and arrested cerebral adrenoleukodystrophy using quantitative MR imaging-based lesion volumetry. MATERIALS AND METHODS: We retrospectively...

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Identifiers

PMID: 34503945
DOI: 10.3174/ajnr.A7250
PMCID: PMC8562733

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