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Article

The genetic landscape of human functional brain connectivity.

Nature communications - 24 Feb 2026

Maciel Bernardo de Apc, Schipper Marijn, Romero Cato, de Leeuw Christiaan, Helwegen Koen, Posthuma Danielle, Savage Jeanne E, van den Heuvel Martijn P

Abstract excerpt

Investigating the genetic underpinnings of functional brain connectivity is essential to understand how genetic variation influences brain health and disease. Here, a mass-univariate approach was adopted to study the genetic architecture of functional brain circuitry (Ntotal = 28,159 subjects) with high spatial resolution (82 brain regions). Common genetic variants explained individual differences in 33% of all...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41735316
DOI: 10.1038/s41467-026-69442-9
PMCID: PMC13043896

Genes

APOE
PAX8
SLC39A12
THBS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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