Article
Infant Metabolome in Relation to Prenatal DHA Supplementation and Maternal Single-Nucleotide Polymorphism rs174602: Secondary Analysis of a Randomized Controlled Trial in Mexico.
The Journal of nutrition - 2 Nov 2021
Tandon Sonia, Gonzalez-Casanova Ines, Barraza-Villarreal Albino, Romieu Isabelle, Demmelmair Hans, Jones Dean P, Koletzko Berthold, Stein Aryeh D, Ramakrishnan Usha
Abstract excerpt
BACKGROUND: Although DHA (22:6n-3) is critical for fetal development, results from randomized controlled trials (RCTs) of prenatal DHA supplementation report inconsistent effects on offspring health. Variants in fatty acid desaturase (FADS) genes that regulate the conversion of n-3 and n-6 essential fatty acids into their biologically active derivatives may explain this heterogeneity. OBJECTIVES: We investigated...
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