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Article

Lipid metabolism is associated with developmental epigenetic programming

7 Oct 2016

Abstract excerpt

Maternal diet and metabolism impact fetal development. Epigenetic reprogramming facilitates fetal adaptation to these in utero cues. To determine if maternal metabolite levels impact infant DNA methylation globally and at growth and development genes, we followed a clinical birth cohort of 40 mother-infant dyads. Targeted metabolomics and quantitative DNA methylation were analyzed in 1st trimester maternal plasma...

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PMID: 27713555
DOI: 10.1038/srep34857

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