Maternal FADS2 single nucleotide polymorphism modified the impact of prenatal docosahexaenoic acid (DHA) supplementation on child neurodevelopment at 5 years: Follow-up of a randomized clinical trial.

doi:10.1016/j.clnu.2021.08.026

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Maternal FADS2 single nucleotide polymorphism modified the impact of prenatal docosahexaenoic acid (DHA) supplementation on child neurodevelopment at 5 years: Follow-up of a randomized clinical trial.

Clinical nutrition (Edinburgh, Scotland) - 1 Oct 2021

Gonzalez Casanova Ines, Schoen Meriah, Tandon Sonia, Stein Aryeh D, Barraza Villarreal Albino, DiGirolamo Ann M, Demmelmair Hans, Ramirez Silva Ivonne, Feregrino Raquel Garcia, Rzehak Peter, Stevenson India, Standl Marie, Schnaas Lourdes, Romieu Isabelle, Koletzko Berthold, Ramakrishnan Usha

Abstract excerpt

BACKGROUND: Variability in the FADS2 gene, which codifies the Delta-6 Desaturases and modulates the conversion of essential n-3 and n-6 fatty acids into long-chain polyunsaturated fatty acids, might modify the impact of prenatal supplementation with n-3 docosahexaenoic acid (DHA) on neurodevelopment. OBJECTIVE: To assess if maternal FADS2 single nucleotide polymorphisms (SNPs) modified the effect of prenatal DHA...

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PMID: 34543890
DOI: 10.1016/j.clnu.2021.08.026
PMCID: PMC10515274

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