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Enhancing public health surveillance: a comparative study of platform-specific and hybrid assembly approaches in SARS-CoV-2 genome sequencing.

Microbial genomics - 1 Jul 2025

Coşgun Yasemin, Yalçın Süleyman, Dedeoğlu Ege, Ünal Gültekin, Kopp Katharina, Musul Biran, Sağtaş Ekrem, Raftery Philomena, Korukluoğlu Gülay, Kaygusuz Sedat

Abstract excerpt

During the COVID-19 pandemic, next-generation sequencing (NGS) has been instrumental for public health laboratories in tracking severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations and informing responses. Illumina systems and Oxford Nanopore Technologies (ONT) have been primary tools for NGS, each presenting unique advantages. The hybrid assembly (HA) approach, integrating short- and long-read...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40637372
DOI: 10.1099/mgen.0.001357
PMCID: PMC12244368

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