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Article

The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment

1 Sept 2021

Abstract excerpt

This study describes the elucidation of (2E)-N-benzyl-3-(4-butoxyphenyl)prop-2-enamide (SBI-0090799) as a selective and potent inhibitor of Zika virus (ZIKV) replication using a high-throughput screening approach. Mapping and resistance studies, supported by electron microscopy observations, indicate that the small molecule is functioning through inhibition of NS4A-mediated formation of ZIKV replication...

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Identifiers

PMID: 34468177
DOI: 10.1128/jvi.00996-21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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