Article
Interferon alpha-2 treatment reduces circulating neutrophil extracellular trap levels in myeloproliferative neoplasms.
British journal of haematology - 1 Jul 2023
Massarenti Laura, Knudsen Trine Alma, Enevold Christian, Skov Vibe, Kjaer Lasse, Larsen Morten K, Larsen Thomas S, Hansen Dennis L, Hasselbalch Hans C, Nielsen Claus H
Abstract excerpt
Neutrophil extracellular traps (NETs) may play a pathogenic role in the thrombosis associated with myeloproliferative neoplasms (MPNs). We measured serum NET levels in 128 pretreatment samples from patients with MPNs and in 85 samples taken after 12 months of treatment with interferon alpha-2 (PEG-IFNα-2) formulations or hydroxyurea (HU). No differences in NET levels were observed across subdiagnoses or...
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