Article
The Interleukin-6/Signal Transducer and Activator of Transcription-3/Cystathionine γ-Lyase Axis Deciphers the Transformation Between the Sensitive and Resistant Phenotypes of Breast Cancer Cells.
Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2021
Tan Zhaoyi, Ge Chun, Feng Dong, Xu Chen, Cao Bei, Xie Yuan, Zhou Honghao, Wang Guangji, Aa Jiye
Abstract excerpt
Drug resistance of cancer cells is associated with redox homeostasis. The mechanism of acquired resistance of cancer cells to antitumor drugs is not well understood. Our previous studies revealed that drug resistance and highly expressed P-glycoprotein (P-gp) of MCF-7 breast cancer cells was dependent on intracellular redox homeostasis and declined capacity for scavenging reactive oxygen species (ROS). Recently,...
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