Detection of archived lamivudine-associated resistance mutations in virologically suppressed, lamivudine-experienced HIV-infected adults by different genotyping techniques (GEN-PRO study).

doi:10.1093/jac/dkab323

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Article

Detection of archived lamivudine-associated resistance mutations in virologically suppressed, lamivudine-experienced HIV-infected adults by different genotyping techniques (GEN-PRO study).

The Journal of antimicrobial chemotherapy - 12 Nov 2021

Montejano Rocio, Dominguez-Dominguez Lourdes, de Miguel Rosa, Rial-Crestelo David, Esteban-Cantos Andrés, Aranguren-Rivas Paula, García-Álvarez Mónica, Alejos Belén, Bisbal Otilia, Santacreu-Guerrero Mireia, Hernando Asunción, Bermejo-Plaza Laura, Cadiñanos Julen, Mayoral Mario, Castro Juan Miguel, Moreno Victoria, Martin-Carbonero Luz, Rodés Berta, Delgado Rafael, Rubio Rafael, Pulido Federico, Arribas José Ramón

Abstract excerpt

BACKGROUND: Previously selected lamivudine resistance-associated mutations (RAMs) may remain archived within the proviral HIV-DNA. OBJECTIVES: To evaluate the ability of proviral DNA genotyping to detect lamivudine RAMs in HIV-1 virologically suppressed participants; the correlation between Sanger and next generation sequencing (NGS); and predictive factors for detection of lamivudine RAMs in proviral DNA....

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PMID: 34459889
DOI: 10.1093/jac/dkab323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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