Article
Association study between Van der Woude Syndrome causative gene GRHL3 and nonsyndromic cleft lip with or without cleft palate in a Chinese cohort.
Gene - 15 Aug 2016
Wang Yirui, Sun Yimin, Huang Yongqing, Pan Yongchu, Jia Zhonglin, Ma Lijuan, Ma Lan, Lan Feifei, Zhou Yuxi, Shi Jiayu, Yang Xiong, Zhang Lei, Jiang Hongbing, Jiang Min, Yin Aihua, Cheng Jing, Wang Lin, Yang Yinxue, Shi Bing
Abstract excerpt
Cleft lip with or without cleft palate (CL/P) is one of the most common birth defects worldwide and is characterized by abnormalities of the orofacial structure. Syndromic CL/P is mainly caused by Mendelian disorders such as Van der Woude Syndrome (VWS). However, >70% of CL/P cases are nonsyndromic, characterized by isolated orofacial cleft without any known syndrome. The etiology of nonsyndromic CL/P (NSCL/P)...
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