Article
A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3.
American journal of human genetics - 7 Apr 2016
Leslie Elizabeth J, Liu Huan, Carlson Jenna C, Shaffer John R, Feingold Eleanor, Wehby George, Laurie Cecelia A, Jain Deepti, Laurie Cathy C, Doheny Kimberly F, McHenry Toby, Resick Judith, Sanchez Carla, Jacobs Jennifer, Emanuele Beth, Vieira Alexandre R, Neiswanger Katherine, Standley Jennifer, Czeizel Andrew E, Deleyiannis Frederic, Christensen Kaare, Munger Ronald G, Lie Rolv T, Wilcox Allen, Romitti Paul A, Field L Leigh, Padilla Carmencita D, Cutiongco-de la Paz Eva Maria C, Lidral Andrew C, Valencia-Ramirez Luz Consuelo, Lopez-Palacio Ana Maria, Valencia Dora Rivera, Arcos-Burgos Mauricio, Castilla Eduardo E, Mereb Juan C, Poletta Fernando A, Orioli Iêda M, Carvalho Flavia M, Hecht Jacqueline T, Blanton Susan H, Buxó Carmen J, Butali Azeez, Mossey Peter A, Adeyemo Wasiu L, James Olutayo, Braimah Ramat O, Aregbesola Babatunde S, Eshete Mekonen A, Deribew Milliard, Koruyucu Mine, Seymen Figen, Ma Lian, de Salamanca Javier Enríquez, Weinberg Seth M, Moreno Lina, Cornell Robert A, Murray Jeffrey C, Marazita Mary L
Abstract excerpt
Cleft palate (CP) is a common birth defect occurring in 1 in 2,500 live births. Approximately half of infants with CP have a syndromic form, exhibiting other physical and cognitive disabilities. The other half have nonsyndromic CP, and to date, few genes associated with risk for nonsyndromic CP have been characterized. To identify such risk factors, we performed a genome-wide association study of this disorder....
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