Article
Sarcoidosis--immunopathogenetic concepts.
Seminars in respiratory and critical care medicine - 1 Feb 2007
Zissel Gernot, Prasse Antje, Müller-Quernheim Joachim
Abstract excerpt
Sarcoidosis is a chronic granulomatous disorder characterized by an accumulation of activated lymphocytes, predominantly T helper cells, expressing the Th1 phenotype and macrophages at sites of disease activity. Although the cause of sarcoidosis has not been elucidated, several lines of evidence suggest that granuloma formation results from exposure to one or more antigens, eliciting a T lymphocyte response. The...
Topics
- Antigen-Presenting Cells
- Cell Proliferation
- Colony-Stimulating Factors
- Cytokines
- Genetic Predisposition to Disease
- Granuloma, Respiratory Tract
- Humans
- Macrophages, Alveolar
- Polymorphism, Genetic
- Receptors, Antigen, T-Cell