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Article

Natural Mutations Affect Structure and Function of gC1q Domain of Otolin-1.

International journal of molecular sciences - 23 Aug 2021

Hołubowicz Rafał, Ożyhar Andrzej, Dobryszycki Piotr

Abstract excerpt

Otolin-1 is a scaffold protein of otoliths and otoconia, calcium carbonate biominerals from the inner ear. It contains a gC1q domain responsible for trimerization and binding of Ca2+. Knowledge of a structure-function relationship of gC1q domain of otolin-1 is crucial for understanding the biology of balance sensing. Here, we show how natural variants alter the structure of gC1q otolin-1 and how Ca2+ are able to...

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Identifiers

PMID: 34445792
DOI: 10.3390/ijms22169085
PMCID: PMC8396674

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