Article
Next-generation sequencing implicates oncogenic roles for p53 and JAK/STAT signaling in microcystic adnexal carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2020
Chan May P, Plouffe Komal R, Liu Chia-Jen, Palanisamy Nallasivam, Carskadon Shannon, Zhao Lili, Nazarian Rosalynn M, Durham Alison B, Johnson Timothy M, Andea Aleodor A, Patel Rajiv M, Lowe Lori, Fullen Douglas R, Brown Noah A, Tomlins Scott A, Udager Aaron M, Harms Paul W
Abstract excerpt
Microcystic adnexal carcinoma is a locally aggressive sweat gland carcinoma characterized by its infiltrative growth and histopathologic overlap with benign adnexal tumors, often posing challenges to both diagnosis and management. Understanding the molecular underpinnings of microcystic adnexal carcinoma may allow for more accurate diagnosis and identify potential targetable oncogenic drivers. We characterized 18...
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