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Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

25 Aug 2021

Abstract excerpt

The spread of the SARS-CoV-2 variants, especially the global variants of concern (VOCs), could seriously dampen our efforts to tackle the COVID-19 pandemic. The SARS-CoV-2 spike protein recognizes the host angiotensin-converting enzyme 2 (ACE2) via its receptor-binding domain (RBD) to mediate viral entry into the cells. Several notorious mutations have been identified in the spike RBD of the VOCs. For example,...

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PMID: 34433900
DOI: 10.1038/s41422-021-00555-0

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