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Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses

25 Aug 2021

Abstract excerpt

The transcriptome of SARS-CoV-2-infected cells that reflects the interplay between host and virus has provided valuable insights into mechanisms underlying SARS-CoV-2 infection and COVID-19 disease progression. In this study, we show that SARS-CoV-2 can establish a robust infection in HEK293T cells that overexpress human angiotensin-converting enzyme 2 (hACE2) without triggering significant host immune response....

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PMID: 34433867
DOI: 10.1038/s41598-021-96462-w

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