Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma.

Cancer research - 15 Nov 2021

Zhang Shanshan, Zhou Yu-Feng, Cao Jian, Burley Stephen K, Wang Hui-Yun, Zheng X F Steven

Abstract excerpt

The SWI/SNF chromatin remodeling complexes control accessibility of chromatin to transcriptional and coregulatory machineries. Chromatin remodeling plays important roles in normal physiology and diseases, particularly cancer. The ARID1A-containing SWI/SNF complex is commonly mutated and thought to be a key tumor suppressor in hepatocellular carcinoma (HCC), but its regulation in response to oncogenic signals...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanistic Target of Rapamycin Complex 1

Share to Proteolysis

Share to Survival Rate

Share to TOR Serine-Threonine Kinases

Share to Ubiquitination

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 34429326
DOI: 10.1158/0008-5472.CAN-21-0206
PMCID: PMC8595749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma.PMID 34429326Read ↗

Targeting ARID1A mutations in cancer.Semantic proximity Read ↗

Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathwaySemantic proximity Read ↗

Chromatin remodeling gene<i>ARID2</i>targets cyclin D1 and cyclin E1 to suppress hepatoma cell progressionSemantic proximity Read ↗

ARID1A loss in cancer: Towards a mechanistic understanding.Semantic proximity Read ↗

The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression?Semantic proximity Read ↗

ARID1A and Its Impact Across the Hallmarks of CancerSemantic proximity Read ↗

HDAC2 Provides a Critical Support to Malignant Progression of Hepatocellular Carcinoma through Feedback Control of mTORC1 and AKTSemantic proximity Read ↗

The emerging roles of ARID1A in tumor suppression.Semantic proximity Read ↗

Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma—rationale for targeting ARID1A deficiencySemantic proximity Read ↗

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.Semantic proximity Read ↗

Decreased expression of ARID1A associates with poor prognosis and promotes metastases of hepatocellular carcinomaSemantic proximity Read ↗

Remodeling of the ARID1A tumor suppressor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.