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The Bardet–Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly

12 Jul 2021

Abstract excerpt

Components of the intraflagellar transport (IFT) system that regulates the assembly of the primary cilium are co-opted by the non-ciliated T cell to orchestrate polarized endosome recycling and to sustain signaling during immune synapse formation. Here, we investigated the potential role of Bardet-Biedl syndrome 1 protein (BBS1), an essential core component of the BBS complex that cooperates with the IFT system...

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PMID: 34423835
DOI: 10.1242/jcs.258462

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Related research

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The Bardet–Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assemblyPMID 34423835Read ↗

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