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Article

Comparative genomics of Enterobacter cloacae complex before and after acquired clinical resistance to Ceftazidime-Avibactam.

Diagnostic microbiology and infectious disease - 1 Dec 2021

Senchyna Fiona, Tamburini Fiona B, Murugesan Kanagavel, Watz Nancy, Bhatt Ami S, Banaei Niaz

Abstract excerpt

Resistance to Ceftazidime-Avibactam in Enterobacter cloacae is poorly understood. Whole genome sequencing identified 6 variants in isolates collected from a patient before and after acquiring Ceftazidime-Avibactam resistance. This included a Phe396Leu mutation in acrB, a component of the AcrAB-TolC efflux pump, possibly mediating enhanced efflux of Ceftazidime and/ or Avibactam.

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Source

Identifiers

PMID: 34418822
DOI: 10.1016/j.diagmicrobio.2021.115511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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