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Article

Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler's Murine Encephalomyelitis Virus (TMEV) infection.

PloS one - 1 Jan 2021

Lawley Koedi S, Rech Raquel R, Elenwa Faith, Han Gang, Perez Gomez Aracely A, Amstalden Katia, Welsh C Jane, Young Colin R, Threadgill David W, Brinkmeyer-Langford Candice L

Abstract excerpt

Host genetic background is a significant driver of the variability in neurological responses to viral infection. Here, we leverage the genetically diverse Collaborative Cross (CC) mouse resource to better understand how chronic infection by Theiler's Murine Encephalomyelitis Virus (TMEV) elicits diverse clinical and morphologic changes in the central nervous system (CNS). We characterized the TMEV-induced...

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Identifiers

PMID: 34415947
DOI: 10.1371/journal.pone.0256370
PMCID: PMC8378701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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