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Article

Increased gene expression and copy number of mutated blaKPC lead to high-level ceftazidime/avibactam resistance in Klebsiella pneumoniae.

BMC microbiology - 19 Aug 2021

Sun Lingxiao, Li Haibo, Wang Qi, Liu Yingmei, Cao Bin

Abstract excerpt

BACKGROUND: Resistance to ceftazidime-avibactam was reported, and it is important to investigate the mechanisms of ceftazidime/avibactam resistance in K. pneumoniae with mutations in blaKPC. RESULTS: We report the mutated blaKPC is not the only mechanism related to CZA resistance, and investigate the role of outer porin defects, efflux pump, and relative gene expression and copy number of blaKPC and ompk35/36....

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Identifiers

PMID: 34412588
DOI: 10.1186/s12866-021-02293-0
PMCID: PMC8375111

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