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Article

Generation of desminopathy in rats using CRISPR-Cas9.

Journal of cachexia, sarcopenia and muscle - 1 Oct 2020

Langer Henning T, Mossakowski Agata A, Willis Brandon J, Grimsrud Kristin N, Wood Joshua A, Lloyd Kevin C K, Zbinden-Foncea Hermann, Baar Keith

Abstract excerpt

BACKGROUND: Desminopathy is a clinically heterogeneous muscle disease caused by over 60 different mutations in desmin. The most common mutation with a clinical phenotype in humans is an exchange of arginine to proline at position 350 of desmin leading to p.R350P. We created the first CRISPR-Cas9 engineered rat model for a muscle disease by mirroring the R350P mutation in humans. METHODS: Using CRISPR-Cas9...

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Identifiers

PMID: 32893996
DOI: 10.1002/jcsm.12619
PMCID: PMC7567154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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