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Mutation analysis of SOD1, C9orf72, TARDBP and FUS genes in ethnically-diverse Malaysian patients with amyotrophic lateral sclerosis (ALS).

Neurobiology of aging - 1 Dec 2021

Edgar Suzanna, Ellis Melina, Abdul-Aziz Nur Adilah, Goh Khean-Jin, Shahrizaila Nortina, Kennerson Marina L, Ahmad-Annuar Azlina

Abstract excerpt

Recent studies have identified SOD1, FUS, TARDBP and C9orf72 as major ALS-related genes in both European and Asian populations. However, significant differences exist in the mutation frequencies of these genes between various ancestral backgrounds. This study aims to identify the frequency of mutations in the common causative ALS genes in a multi-ethnic Malaysian cohort. We screened 101 Malaysian ALS patients...

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PMID: 34404558
DOI: 10.1016/j.neurobiolaging.2021.07.008

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