Article
The distinct genetic pattern of ALS in Turkey and novel mutations.
Neurobiology of aging - 1 Apr 2015
Özoğuz Aslıhan, Uyan Özgün, Birdal Güneş, Iskender Ceren, Kartal Ece, Lahut Suna, Ömür Özgür, Agim Zeynep Sena, Eken Aslı Gündoğdu, Sen Nesli Ece, Kavak Pınar, Saygı Ceren, Sapp Peter C, Keagle Pamela, Parman Yeşim, Tan Ersin, Koç Filiz, Deymeer Feza, Oflazer Piraye, Hanağası Haşmet, Gürvit Hakan, Bilgiç Başar, Durmuş Hacer, Ertaş Mustafa, Kotan Dilcan, Akalın Mehmet Ali, Güllüoğlu Halil, Zarifoğlu Mehmet, Aysal Fikret, Döşoğlu Nilgün, Bilguvar Kaya, Günel Murat, Keskin Özlem, Akgün Tahsin, Özçelik Hilmi, Landers John E, Brown Robert H, Başak A Nazlı
Abstract excerpt
The frequency of amyotrophic lateral sclerosis (ALS) mutations has been extensively investigated in several populations; however, a systematic analysis in Turkish cases has not been reported so far. In this study, we screened 477 ALS patients for mutations, including 116 familial ALS patients from 82 families and 361 sporadic ALS (sALS) cases. Patients were genotyped for C9orf72 (18.3%), SOD1 (12.2%), FUS (5%),...
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