Article
Novel and rare variants in amyotrophic lateral sclerosis genes identified in Malaysian patients.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 May 2026
Zulhairy-Liong Nurul Angelyn, Edgar Suzanna, Ellis Melina, Zhu Danqing, Lai Kaitao, Capelle David Paul, Sabirin Sakinah, Pek Eu Way, Nair Prasana, Ang Chui Munn, Kennerson Marina L, Shahrizaila Nortina, Ahmad-Annuar Azlina
Abstract excerpt
There is limited information on the genetic architecture of amyotrophic lateral sclerosis (ALS) in Southeast Asian populations. To address this knowledge gap, we performed 1) SOD1 (exon 1-4), FUS (exon 13-15), TARDBP (exon 6) and ATXN2 repeat expansion screening in 201 multi-ethnic Malaysian (Malay, Chinese, Indian and others) ALS patients, 2) C9orf72 repeat expansion testing in 179 subset patients, and 3) a...
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