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Article

Cardiac myosin binding protein-C variants in paediatric-onset hypertrophic cardiomyopathy: natural history and clinical outcomes.

Journal of medical genetics - 1 Aug 2022

Field Ella, Norrish Gabrielle, Acquaah Vanessa, Dady Kathleen, Cicerchia Marcos Nicolas, Ochoa Juan Pablo, Syrris Petros, McLeod Karen, McGowan Ruth, Fell Hannah, Lopes Luis R, Cervi Elena, Kaski Juan Pablo Pablo

Abstract excerpt

BACKGROUND: Variants in the cardiac myosin-binding protein C gene (MYBPC3) are a common cause of hypertrophic cardiomyopathy (HCM) in adults and have been associated with late-onset disease, but there are limited data on their role in paediatric-onset HCM. The objective of this study was to describe natural history and clinical outcomes in a large cohort of children with HCM and pathogenic/likely pathogenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34400558
DOI: 10.1136/jmedgenet-2021-107774
PMCID: PMC7613139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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